OsteoProbe® is a portable handheld impact microindenter that measures the ability of bone material to resist indentation. Unlike radiological or imaging methods (X-ray, DXA and CT) that measure bone mineral density and bone mineral structure, OsteoProbe® measures bone material quality, which is an independent component of bone strength. OsteoProbe® is for research use only in the United States.
OsteoProbe® uses Reference Point Indentation (RPI) technology to investigate the bone material’s ability to resist a localized force (resist separation of mineralized collagen fibrils). This is quantified by the Bone Material Strength index (BMSi) or Bone Score™.
How OsteoProbe Quantifies Quality
OsteoProbe® utilizes a needle-like tip specifically designed for making subcutaneous measurements without the need for an incision. The tip penetrates through the soft tissue down to the bone surface where it establishes a localized reference point. Once a preload threshold is reached, OsteoProbe automatically triggers a second actuation of higher force that performs the official measurement. Indentation depth as a function of force is recorded and then normalized to a calibrated reference material to calculate a Bone Score™.
What is the Bone Score?
Once a patient is measured, the device displays that patient's Bone Score™.
The Bone Score™ is an easy to understand scale that ranges from 40 to 100.
Since this technique is still very new, a healthy reference interval is being established to help guide physicians with their decision making. Once established by the clinical research community, patients will be ranked in four categories based on the numerical output:
- Above Average
Clinical research is ongoing to accurately define the healthy reference interval for the Bone Score™.
How do you use OsteoProbe?
OsteoProbe uses a single-use sterilized tip to measure bone material quality without an incision. The measurement process is straight forward:
Step 1 - Apply local anesthetic
Percutaneous measurements are made at the mid-shaft of the left or right tibia. After cleaning the region, apply a local anesthetic to numb the skin and periosteium.
Clinical Evidence and Research
OsteoProbe has been extensively tested in clinical research studies covering a wide range of indications. As the technique becomes more common, further refinement and improvement of the test will be possible.
Type 2 Diabetes
2017 Bone – Hospital del Mar – Dr Adolfo Diez Perez (bisphosphonates & Fx)
* see ASBMR abstract below on Exercise
2015 JBMR – Oslo Univ – Dr Erik Eriksen (Norway vs Spain)
2015 JCEM – Leiden Univ – Dr Socrates Papapolous (Osteopenia & Fx)
2015 JBMR – Gothenberg – Dr Mattias Lorentzon (Population Study)
2017 Cal Tis Intl – Oslo Univ – Dr Erik Eriksen (Osteoporotic Fx & Spinal Fx)
2017 Osteoporos Int – Leiden Univ – Dr Socrates Papapolous (Fx Site Relevance)
Procedural Overview / Safety
2017 Osteoporos Int – Hospital del Mar – Dr Adolfo Diez Perez (Pre-transplant)
2017 Transplantation – Hospital del Mar – Dr Adolfo Diez Perez (Long term post-transplant)
ASBMR 2016 Abstract on Exercise | Atlanta Georgia
Plenary Sessions, Presentation Number: FR0251
Session: Welcome Reception & Plenary Poster Session
Poster Sessions, Presentation Number: SA0251
Instructions for Use
To request a hard copy of the User Manual, please contact us here.