Enabling clinicians to directly quantify bone quality

OsteoProbe® is a portable handheld impact microindenter that measures the ability of bone material to resist indentation. Unlike radiological or imaging methods (X-ray, DXA and CT) that measure bone mineral density and bone mineral structure, OsteoProbe® measures bone material quality, which is an independent component of bone strength. OsteoProbe® is for research use only in the United States.

OsteoProbe® uses Reference Point Indentation (RPI) technology to investigate the bone material’s ability to resist a localized force (resist separation of mineralized collagen fibrils). This is quantified by the Bone Material Strength index (BMSi) or Bone Score™.

How OsteoProbe Quantifies Quality

OsteoProbe® utilizes a needle-like tip specifically designed for making subcutaneous measurements without the need for an incision. The tip penetrates through the soft tissue down to the bone surface where it establishes a localized reference point. Once a preload threshold is reached, OsteoProbe automatically triggers a second actuation of higher force that performs the official measurement. Indentation depth as a function of force is recorded and then normalized to a calibrated reference material to calculate a Bone Score™.

This chart contains example data and has no clinical significance.

What is the Bone Score?

Once a patient is measured, the device displays that patient's Bone Score™.

The Bone Score™ is an easy to understand scale that ranges from 40 to 100.

Since this technique is still very new, a healthy reference interval is being established to help guide physicians with their decision making. Once established by the clinical research community, patients will be ranked in four categories based on the numerical output:

  • Above Average
  • Average
  • Decreased
  • Low

Clinical research is ongoing to accurately define the healthy reference interval for the Bone Score™.

How do you use OsteoProbe?

OsteoProbe uses a single-use sterilized tip to measure bone material quality without an incision. The measurement process is straight forward:

Step 1 - Apply local anesthetic

Percutaneous measurements are made at the mid-shaft of the left or right tibia. After cleaning the region, apply a local anesthetic to numb the skin and periosteium.

Step 2 - Perform measurement

Insert through skin

Place a single-use sterilized tip on the OsteoProbe and insert through the skin to the tibia surface.

Compress housing

Compress the outer housing of the OsteoProbe.

Impact the bone

When fully compressed, the device impacts the bone at a constant force and measures the indentation distance increase from the impact.

Step 3 - Measure reference material

After the software indicates measurements on the patient are complete, measure the reference material that was provided with the single-use tip to calculate the patient's Bone Score™.

Clinical Evidence and Research

OsteoProbe has been extensively tested in clinical research studies covering a wide range of indications. As the technique becomes more common, further refinement and improvement of the test will be possible.

Clinical Publications

Type 2 Diabetes

2013 JBMR – Mayo Clinic – Sundeep Khosla

2016 JCEM – Columbia – Dr Mishaela Rubin

2017 JBMR – Gothenberg Univ – Dr Mattias Lorentzon

 

Treatment Tracking

2015 JBMR – Hospital del Mar – Dr Adolfo Diez Perez (GIOP & Tx)

2017 Bone – Hospital del Mar – Dr Adolfo Diez Perez (bisphosphonates & Fx)

* see ASBMR abstract below on Exercise

 

Bone Fragility

2015 JBMR – Oslo Univ – Dr Erik Eriksen (Norway vs Spain)

2015 JCEM – Leiden Univ – Dr Socrates Papapolous (Osteopenia & Fx)

2015 JBMR – Gothenberg – Dr Mattias Lorentzon (Population Study)

2017 Cal Tis Intl – Oslo Univ – Dr Erik Eriksen (Osteoporotic Fx & Spinal Fx)

2017 Osteoporos Int – Leiden Univ – Dr Socrates Papapolous (Fx Site Relevance)

 

Procedural Overview / Safety

2016 Bone Reports – Collaboration of KOLs

2016 Clinical Experience – Dr Adolfo Diez Perez

 

Kidney Transplant

2017 Osteoporos Int – Hospital del Mar – Dr Adolfo Diez Perez (Pre-transplant)

2017 Transplantation – Hospital del Mar – Dr Adolfo Diez Perez (Long term post-transplant)

 

Other Topics

Adipose Tissue – 2015 JBMR – Gothenberg – Dr Mattias Lorentzon

Stress Fracture – 2016 Acta Ortho – Oslo Univ – Dr Erik Eriksen

HIV – 2016 Bone Reports – Hospital del Mar – Dr Adolfo Diez Perez

HIV & Tx – 2017 JAIDS – Hospital del Mar – Dr Adolfo Diez Perez

Gaucher Disease – 2017 JBMR  – Hospital del Mar – Dr Adolfo Diez Perez

Acromegaly – 2017 EJE – Leiden Univ – Dr Socrates Papapolous

 

ASBMR 2016 Abstract on Exercise | Atlanta Georgia

High Impact Mechanical Loading Increases Bone Material Strength – Results from a 3-Month Intervention Study

Plenary Sessions, Presentation Number: FR0251

Session: Welcome Reception & Plenary Poster Session

Poster Sessions, Presentation Number: SA0251